A univariate analysis identified the following significant factors linked to frailty; age (p = 0.0002), presence of LC (p < 0.0001), serum albumin (p < 0.0001), physical functioning (p < 0.0001), role physical (p < 0.0001), bodily pain (p < 0.0001), general health perception (p < 0.0001), vitality (p < 0.0001), social functioning (p < 0.0001), role emotion (p < 0.0001), and mental health (p < 0.0001) (Table 2). This evidence concerns the gene ALB and laryngotracheoesophageal cleft.