TTN and autosomal dominant centronuclear myopathy: To date, at least nine different genes (MTM1, DNM2, RYR1, BIN1, MYF6, CCDC78, TTN, SPEG, ZAK), with a variable mode of inheritance (X-linked, autosomal dominant or recessive), have been implicated in centronuclear myopathies [1,2,4].