TTN and autosomal dominant centronuclear myopathy: In fact, it is worth mentioning that, contrary to core or centronuclear myopathies caused by other genes, TTN-related CMs may be associated with cardiac involvement, but not ophthalmoplegia and, similarly to other CMs, muscle MRI is a powerful tool in their diagnostic work-up, usually showing selective involvement of posterior thigh, soleus and peroneal muscles [188].