Endorepellin can further be processed by the bone morphogenetic protein 1 (BMP1)/Tolloid-like protease and releases the bioactive angiostatic laminin G-like domain 3 (LG3) domain, which can also be found in the secretome of CRC cells suggesting that it may play an important role in this context [84]. The gene discussed is HSPG2; the disease is colorectal carcinoma.