The EMILIN-2 effect in GC is dual, acting directly on GC cells to impair their proliferation and increasing the apoptotic rate and indirectly on EC and angiogenesis by enhancing the expression of angiogenic cytokines as serine protease inhibitor 1 (SERPINE-1), VEGFA, and IL-8 by GC cells [129]. This evidence concerns the gene CXCL8 and gastric cancer.