Multimerin-2 and Elastin microfibril interfacer 2 (EMILIN-2) are two ECM proteins, both belonging to the EMI domain endowed (EDEN) family [111,112,113,114], that display key functions in angiogenesis and have been extensively studied in the context of GI tumors. Here, MMRN2 is linked to digestive system neoplasm.