Given that we show that Hakin-1 exerts an antitumour activity in LoVo and HT-29 colon cancer cells, by inhibiting proliferation, colony formation, migration and invasiveness, accompanied by an increase of E-cadherin expression at cell–cell contacts, we propose that Hakin-1 has promising therapeutic potential against colon cancer growth and progression. This evidence concerns the gene CDH1 and malignant colon neoplasm.