SOD1 and amyotrophic lateral sclerosis: To date we can summarize genetic findings generally where Familial ALS cases show high heritability and the identification of several genetic associations have been made, in particular they are most frequently mutations or polymorphisms in Super Oxide Dismutase-1 (SOD-1), RNA-binding protein Sarcoma/Translocated in Liposarcoma or FUS/TLS, Trans-activation response (TAR) DNA Binding Protein and chromosome nine open reading frame (C9ORF72) [39,40].