Work by Dwivedi et al. [36] demonstrates that PCSK9 deficiency extends protection against systemic bacterial dissemination, organ pathology, and tissue inflammation, particularly in the lungs and in the liver, while PCSK9 overexpression exacerbates multi-organ pathology as well as the hypercoagulable and pro-inflammatory states in early sepsis. Here, PCSK9 is linked to Sepsis.