Interestingly, a recent study demonstrated that a novel small-molecule STAT3-inhibitor able to block liver inflammation and reduce HCC development/growth in a mouse model of nonalcoholic steatohepatitis exerted a main inhibitory effect on TREM-1 signaling, further linking TREM-1 to the inflammatory processes that promote liver cancer [231]. This evidence concerns the gene TREM1 and metabolic dysfunction-associated steatohepatitis.