Finally, Wu et al. [205] recently demonstrated that TREM-1+ TAMs were abundant in advanced-stage HCC within HIF+ areas and associated with poor prognosis, and that, in orthotopic liver tumor models, TREM-1+ TAMs induced immunosuppression by impairing CD8+T cell cytotoxicity while promoting their apoptosis. Here, CD8A is linked to hepatocellular carcinoma.