TREM-1 blockade by the administration of the GF9 inhibitory peptide significantly suppressed tumor growth, and the therapeutic efficacy was increased by the peptide incorporation into synthetic high-density lipoprotein nanoparticles to extend its half-life and specifically target delivery to macrophages, supporting the TREM-1 potential as a target for adjunctive therapy in lung cancer treatment [237]. This evidence concerns the gene TREM1 and lung cancer.