More recent investigations have linked TREM-1 to the occurrence of acute non-infectious inflammatory diseases, such as acute pancreatitis, myocardial ischemia–reperfusion injury, and hemorrhagic shock, as well as to the perpetuation of several chronic inflammatory conditions, including bowel inflammatory disorders, arthritides, atherosclerosis, hypertrophic scars/ulcers, multiple sclerosis, chronic obstructive pulmonary disease, and chronic hepatic granulomatous inflammation [37,110,153,157,178,217,218,219,220]. The gene discussed is TREM1; the disease is myocardial ischemia.