TREM1 and Sepsis: Two short synthetic peptides, P1 and LP17, derived from the TREM-1 ligand-binding extracellular domain and behaving as decoys for endogenous TREM-1 ligands, have been created and proven to be effective in various preclinical models of microbial infections/sepsis and non-infectious inflammatory conditions by dampening inflammation and protecting from organ damage and death [37,168,178,184,186,188].