In addition, blocking TREM-1 signaling with GF9 treatment in orthotopic HCC-bearing models abrogated the TREM-1+TAM-mediated immunosuppressive effects by significantly reducing Treg recruitment and CD8+T cell apoptosis/dysfunction, showing inhibitory effects on tumor growth and improving mouse survival [205]. The gene discussed is TREM1; the disease is hepatocellular carcinoma.