Finally, a critical role for TREM-1-expressing TAMs in pancreatic cancer progression was shown in xenograft mouse models [232] (see Section 7 for details), and a TREM-1 increased expression was also observed in Mn from patients with invasive cervical cancer [233] and in TAM infiltrating glioblastoma [202]. The gene discussed is TREM1; the disease is glioblastoma.