Zhou and coworkers [235] demonstrated that TREM-1 blocking by the administration of the LP17 peptide antagonist had therapeutic effects in a mouse model of colon carcinogenesis, reducing the histopathological alterations and tumor formation associated with decreased levels of pro-inflammatory cytokine production by intestinal macrophages and epithelial proliferation, suggesting that treatment can attenuate intestinal macrophage-mediated inflammation and progression to colon carcinoma [235]. Here, TREM1 is linked to colon carcinoma.