Thanks to the development of a 3D AD human neuronal cell culture model displaying both extracellular Aβ-deposits (plaques) and the concomitant presence of p-Tau in neurons and fibrillar Tau aggregates like NFT in neurites and cell bodies [86,87], Kwak et al. provided a direct evidence that it exists a direct correlation between Aβ species and Tau pathology in AD [88]. Here, MAPT is linked to Alzheimer disease.