PNPO and diabetes mellitus: Interestingly, in Drosophila, the impact of mutations on diabetes was analyzed in the genes involved in the vitamin B6 salvage pathway, such as pyridoxal kinase (dPdxk) and pyridoxine 5′-phosphate oxidase (sgll). These studies revealed that mutations in the dPdxk gene caused a significant increase in the glucose content of the larval hemolymph (the human blood) [45].