The same study [88] found a decline in MYC levels upon down-regulation of SphK2 expression, which suggests that growth-promoting role of SphK2 in colon cancer is associated with MYC, the latter being an important mediator of cell differentiation, survival, metabolism and chemoresistance with a demonstrated role in CRC tumorigenesis [89]. This evidence concerns the gene MYC and malignant colon neoplasm.