Given that SphK1 plays a central role in the activation of signaling pathways responsible for increased epithelial-mesenchymal transition, which is an important factor contributing to the development of chemoresistance [80,81], the mechanisms by which SphK1 modulates treatment response and development of chemoresistance in colon cancer have been the subject of investigation in different studies. Here, SPHK1 is linked to colonic neoplasm.