AKT1 and malignant colon neoplasm: Gu et al. [43] have reported that Spns2 induces proliferation, migration and invasion and suppresses apoptosis in human colon cancer cells by activating S1P/S1PR1/S1PR3 signaling axis and inducing AKT and ERK signaling pathways, which implicates that Spns2 could be considered as a promising therapeutic target in treating colon cancer.