Both systemic and tumor S1P are important regulators of local tumor growth; however, it is systemic S1P generated by sphingosine kinase 1 rather than tumor-derived S1P that controls tumor metastasis, and inhibition of systemic S1P signaling using anti-S1P monoclonal antibody Sphingomab is able to suppress lung colonization and metastasis of urothelial carcinoma cells [13]. This evidence concerns the gene SPHK1 and neoplasm.