PTK2 and colonic neoplasm: Similarly, Liu et al. reported on the correlation between the expression of SphK1 and FAK or p-FAK, and showed increased expression of activated FAK as well as some other cell adhesion molecules including intercellular cell-adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in colon cancer LOVO cells induced by SphK1 over-expression, while the opposite effect was observed with the suppression of SphK1.