Given that SphK1 plays a central role in the activation of signaling pathways responsible for increased epithelial-mesenchymal transition, which is an important factor contributing to the development of chemoresistance [80,81], the mechanisms by which SphK1 modulates treatment response and development of chemoresistance in colon cancer have been the subject of investigation in different studies. The gene discussed is SPHK1; the disease is malignant colon neoplasm.