Previous studies have demonstrated low levels of expression of LPP1 and LPP3 in different cancer cells and tumors, whereas increased expression of LPP2 has been correlated with cell transformation and accelerated entry into S-phase of the cell cycle, which suggests that LPP2 has an opposite effect on cancer cell growth in comparison with LPP1 and LPP3 [8]. Here, PLPP3 is linked to cancer.