ACE2 and diabetes mellitus: On the other hand, ACE2 enables virus entry into host target cells [14,15,26], raising speculation of increased susceptibility to COVID-19 infection in the case of ACE2 overregulation, as a consequence of long-term treatment with ACE inhibitors and/or ANGII receptor blockers, GLP1 RAs or a combination of both in hypertensive patients with diabetes [15].