AhR and its effects on the NLRP3 inflammasome and colitis have been predominantly studied using wild-type (AhR+/+), AhR knockout (AhR−/−) and heterozygous (AhR−/+) mouse models that have been chemically induced with intestinal inflammation; by using 2,4,6-trinitrobenzene sulphonic acid (TNBS) or dextran sulphate sodium (DSS), and CAC; by using azoxymethane (AOM or AOM/DSS) [70]. Here, AHR is linked to infectious otitis media.