ADCY9 and cancer: For example, according to the enrichment results and KEGG “pathway in cancer” (hsa05200), ADCY9 regulates cGMP-PKG and cAMP signalling pathways to inhibit apoptosis and promote proliferation [63]; the genes NOCA1 and NOCA3 are involved in oestrogen signalling, breast cancer pathway, and cancer cell growth stimulation [64,65]; the genes ARNT and NOTCH3 enhance migration and invasion via angiogenesis by way of endocrine resistance, HIF-1, and notch signalling [66,67] (Figure 3C).