Proteomics studies on AD brains reveal that enzymes involved in metabolic pathways of the Kreb’s cycle and glycolysis including malate dehydrogenase, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), fructose-bis-phosphate-enolase, alpha-enolase (ENO1), and ATP synthase are oxidized [46]. The gene discussed is GAPDH; the disease is Alzheimer disease.