Additionally, TLR7 activation in melanoma is associated with significant increases in: intratumoral CD8+ T and CD4+ T cells [53]; anti-tumor macrophages, B cells, IFNγ, IFNα/β, and plasmacytoid dendritic cells [54], and pro-inflammatory cytokines IL6 and IL12 [55]. This evidence concerns the gene CD4 and melanoma.