NMO had been considered a variant of MS until an autoantibody against the water channel protein aquaporin-4 (AQP4), expressed abundantly on astrocyte end-feet, called AQP4-IgG (also called NMO-IgG), was discovered in patients with NMO, and found to be absent in patients with MS [106,107]. The gene discussed is AQP4; the disease is myeloid sarcoma.