A Pubmed search was conducted for articles published between 2000 and 2020, that included the terms: “acute disseminated encephalomyelitis; “demyelinating diseases”; “glial fibrillary acidic protein”; “multiple sclerosis”; “myelin oligodendrocyte glycoprotein”; “myelitis”; “neuromyelitis optica”; and “spinal cord diseases”. This evidence concerns the gene MOG and demyelinating disease.