CASP8 and Angelman syndrome: Remarkably, random forest bioinformatics analysis of transcriptome data derived from the hippocampi of adult Angelman syndrome model mice [57] showed a significant alteration both in apoptotic (for example, Xiap and Casp8) and proliferative (for example, Foxo1 and Pacap) genes between AS model mice and their WT littermates (Figure 8 and Table S9).