SRPX2 overexpression is involved in cell proliferation, invasion, and metastasis in gastric cancer [11,13], colon cancer [14,15], pancreatic cancer [16,17], glioblastoma [18], and osteosarcoma [19], etc. SRPX2 expression is also associated with poor clinical outcomes in several malignancies [13,17,18,20,21]. This evidence concerns the gene SRPX2 and osteosarcoma.