Although Rh2 dose-dependently inhibited cell differentiation and relevant key molecules’ expression in 3T3-L1 cells, the high concentrations (30–60 μM) of Rh2 and the characteristics of the 3T3-L1 cell line [21] prevent the application of Rh2 to fight obesity in humans. The gene discussed is RHAG; the disease is obesity due to melanocortin 4 receptor deficiency.