Second generation CD19-CARs have been approved by the Food and Drug Administration (FDA) in 2017 and by the European Medicines Agency (EMA) in 2018 for patients with relapsed/refractory diffuse large B cell lymphoma (DLBCL), acute lymphatic leukemia (ALL < 25 years), and primary mediastinal B cell lymphoma (PMBCL), respectively. The gene discussed is CD19; the disease is diffuse large B-cell lymphoma.