Unlike all groups described above, 29.7 ± 1.2% of tumor area of high-grade double-negative p-53 mutant subtype of recurrent NMIBC was occupied by CD8+-expressing cells; more than twice lower T-suppressor population (12.3 ± 0.9%; p = 0.001 intergroup comparison) infiltrated relapsed double-negative p53-expressing bladder carcinoma with low malignant potential. The gene discussed is CD8A; the disease is urinary bladder carcinoma.