CD274 and urothelial carcinoma: We observed that tumors of all groups were infiltrated by PD-L1-expressing CD8+ cells with prevalence of T-suppressor population (more than 10% of all cells) in chemotherapy- and immunotherapy-naive high- and low-grade relapsed luminal and basal NMIBC, and in high- and low-grade luminal and double-negative, high-grade basal relapsed urothelial carcinoma after previously utilized frontline immunotherapy by BCG.