PARP1 and cancer: More recently, focusing on the PARP-trapping mechanism of action of PARPis, researchers have pointed at the restoration of replication fork stability as another emerging way for cancer cells to withstand PARP inhibition; indeed, cytotoxic death deriving from PARPis-induced stalled replication forks may be bypassed by parallel compensatory pathways restoring and restarting the DNA-repair machinery [63].