The BH4 domain of Bcl-2 and Bcl-xL is able to bind other proteins that do not belong to Bcl-2 protein family, allowing them to play a role beyond their classical role in inhibiting apoptosis, in other important cellular functions such as proliferation, autophagy, differentiation, DNA repair, tumor progression, and angiogenesis [6]. Here, BCL2 is linked to neoplasm.