Dependencies of tumor cells on anti-apoptotic Bcl-2 family members can be experimentally determined by the so-called “dynamic BH3 profiling”, where BH3 peptides specific for individual BH3-only proteins are applied to permeabilized cells and allowed to interact with other BH3-containing proteins on the surface of the mitochondria, generating MOMP, after allowing Bax or Bak oligomerization [8]. This evidence concerns the gene BCL2 and neoplasm.