Thus, although LMNA p.R249W is the most frequent mutation for LMNA-associated congenital muscular dystrophy, a severe type of laminopathy [15], and has been found to be related to abnormal nuclear morphology and myogenic differentiation, mislocalization of Lamin B, altered sense of microenvironment stiffness, and DNA damage [16,17,18,19], the causal connections between this mutation and the disease remain mainly unknown. This evidence concerns the gene LMNA and congenital muscular dystrophy.