eIF2α phosphorylation is instrumental in the pre-apoptotic exposure of the endoplasmic reticulum chaperone calreticulin (CALR) on the cell surface [7,24], which stimulates the phagocytosis of portions of the dying cancer cell (with the tumor-associated antigen) by the dendritic cells (DCs) [25]. The gene discussed is CALR; the disease is cancer.