These observations indicated a potential ICD scenario in CRC cells following rafoxanide exposure and were congruent with the ability of other anti-helmintic agents to induce ICD hallmarks (i.e., ivermectin) [40] and cellular release of HMGB1 (e.g., albendazole, mebendazole, oxibendazole) [41]. This evidence concerns the gene HMGB1 and colorectal carcinoma.