These cytotoxic agents can induce a particular form of apoptosis, termed immunogenic cell death (ICD), which is preceded by pre-mortem stress responses (e.g., calreticulin (CALR) exposure on the cell surface, adenosine triphosphate (ATP) and high mobility group box 1 (HMGB1) release) and that allows the cancer cell to be recognized and handled by the immune system [9]. This evidence concerns the gene HMGB1 and cancer.