SOD1 and amyotrophic lateral sclerosis: Interestingly, in the SOD1(G93A) mice that received exosomes-USPIO, the MR images acquired 3 h post-administration and the subsequent histological staining showed that exosomes reached the injured area of the brains of the mice, indicating the ability of ASC-exosomes to home to the lesioned sites in ALS disease (Figure 7B).