The disease is sporadic in 90%–95% of cases, while it is familial in the remaining cases (with an autosomal dominant, autosomal recessive, or X-linked inheritance), and 20% of the familial ALS are due to mutations in the gene encoding for Cu2+/Zn2+ superoxide dismutase (SOD1) [2]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.