The anxiogenic response to intact Galectin-3 content was concomitant with the enhanced pro-inflammatory cytokines (IL-6 and TNF-α release) which negatively correlated with hippocampal BDNF content that was accompanied by GABA-A receptors decline in hippocampus, finally resulting in anxiety-like behavior (Figure 3). The gene discussed is LGALS3; the disease is Anxiety.