In this study, we now aimed to study the association with liver fibrosis more specifically by investigating (1) liver-specific production and expression of OPG during fibrosis development in vivo and in vitro; (2) the fibrotic regulation of OPG production in liver tissue; (3) the response of OPG production to spontaneous resolution and drug (IFNγ)-induced resolution of fibrosis. This evidence concerns the gene TNFRSF11B and Hepatic fibrosis.