More recently, studies on animal models have also been helpful in exploring, together with the motor phenotype, behavior differences between the two sexes: SOD1 G93A males have been shown to display reduced locomotion and exploration and increased anxiety-like behaviors, as well as an increased conditioned cue-freezing response, while impaired intermediate-term spatial memory may be reported in SOD1 G93A females [100]. Here, SOD1 is linked to Anxiety.