We also observed elevated expression of transcripts encoding immune modulatory cytokines including interleukin-6 (Il6), interleukin 33 (Il33), chemokine (C-X-C motif) ligand 1 (Cxcl1), C-X-C motif chemokine 12 (Cxcl12), monocyte chemoattractant protein-1 (MCP-1/Ccl2) and monocyte-chemotactic protein 3 (MCP3/Ccl7) and several members of compliment pathway including C3, C4b, C1s1 and C1s2 in Ly6c1high cluster (Figure 3C,D), suggesting that Ly6c1high CAFs play a role in regulating the immune responses in the tumor microenvironment. This evidence concerns the gene C4B and neoplasm.