TIMP3 and neoplasm: Other genes enriched in this cluster included matrix glycoprotein fibronectin 1 (Fn1) which has a well-established role in tumor development and progression [50,51,52], integrin alpha 1 (Itga1), syndecan 1 (Sdc1), matrix metalloproteinase inhibitors Timp1, Timp2 and Timp3 and galectin 3 (Lgals3), a potential regulator of cell migration, proliferation, angiogenesis, EMT and apoptosis [53] (Figure S2B).