A comparative analysis of fibroblasts derived from normal mammary fat pad and 4T1 tumor-derived CAFs revealed that Ly6c1high CAFs from the tumor share high molecular similarity with Ly6c1high fibroblasts from normal mammary fat pad (Figure S5A–E), expressing common markers such as Ly6c1, Clec3b, Dpt, Ly6a, Htra3, Has1 and Col14a1 (Figure S5A,E). The gene discussed is HTRA3; the disease is neoplasm.