CCN2 and neoplasm: Regardless of the tumor type or tumor site, Ly6c1high CAFs (iCAFs) showed enrichment for Il33, Il6, Ccl7, Cxcl1 and Cxcl12 whereas α-SMAhigh CAFs (myCAFs) expressed high levels of Tgfb1, Tgfb2 and Ctgf (Figure 3D and Figure 4C,G).