UBB and early-onset autosomal dominant Alzheimer disease: For example, the UBB+1 (Ubiquitin-B+1) form of Ub generated as a result of molecular misreading is linked to Alzheimer’s disease (AD), other tauopathies, and polyglutamine (PolyQ) diseases (e.g., Huntington’s disease (HD)) [16,17,18], with the resulting UBB+1 form being shown to inhibit proteasomal proteolysis [19].