AFP and hepatocellular carcinoma: By using these factors, multivariate analysis revealed that WFA±M2BP ≥ 1.85 COI (HR: 5.29, 95% CI: 2.07–13.0, p < 0.001), AFP ≥ 6.0 ng/mL (HR: 4.27, 95% CI: 1.84–9.94, p < 0.001), and the presence of LR3/4 nodules (HR: 8.49, 95%CI: 3.29–21.9, p < 0.001) were independently associated with HCC development.