INS and obesity due to melanocortin 4 receptor deficiency: It is well documented that overweight-associated or obesity-associated HNBP and HT is already in juveniles accompanied with worsened markers of cardiometabolic risk, e.g., with elevated total cholesterol, low-density lipoprotein cholesterol (LDL-C), triacylglycerols, fasting plasma insulin, C-reactive protein (CRP), uric acid, reduced high-density lipoprotein cholesterol (HDL-C), adiponectin, and insulin sensitivity [3,4,15].