TP53 and neoplasm: Although there are encouraging results in locoregional tumor control with Ad-p53 in combination with RT (the group PRT and the group RT developed 5-year locoregional recurrence rates of 6.2% and 28.6% respectively, with p = 0.003), it should be noted that there were no statistically significant differences in 5-year OS rate, PFS rate and distant metastases rate (21.3% vs. 25.85%, p = 0.662).