To further validate the epigenetic modulation potential of SKD and M.SssI, we stably integrated the ZF-SKD and ZF-M.SssI fusion genes into the genome of highly proliferating MDA-MB-231 breast cancer cells, in which high PLOD2 expression was shown to be associated with metastatic potential [30]. The gene discussed is PLOD2; the disease is breast carcinoma.