Furthermore, 6-pyruvoyltetrahydropterin synthase deficiency is a neurodegenerative disease like PD that is treated by levodopa; similarly, dihydropteridine reductase (DHPR) deficiency; the inverse Warburg effect is associated with neurodegenerative diseases like Alzheimer’s disease and PD. Here, PTS is linked to hyperinsulinemic hypoglycemia, familial, 4.