Furthermore, 6-pyruvoyltetrahydropterin synthase deficiency is a neurodegenerative disease like PD that is treated by levodopa; similarly, dihydropteridine reductase (DHPR) deficiency; the inverse Warburg effect is associated with neurodegenerative diseases like Alzheimer’s disease and PD. The gene discussed is PTS; the disease is early-onset autosomal dominant Alzheimer disease.