KRAS and PI3K/AKT are frequently mutated or overexpressed in CRC, leading to hyperactivation of mTORC1, either indirectly via MEK-ERK-RSK-Raptor phosphorylation in the case of KRAS or directly in the case of PI3K/AKT (Figure 1) [6,69,86,87]. This evidence concerns the gene PIK3CA and colorectal carcinoma.