Therefore, in that condition bodily tissues may not only be deprived of the actions of thyroid hormones; their major loss may be due to marked lowering or even absence of iodine's doping effects on the mixture of insufficient numbers of catecholamines and some very small amounts of thyronamines that are likely to be found even in most cases of severe hypothyroidism. The gene discussed is TG; the disease is hypothyroidism.