IL1B and Chagas disease: It would be very convenient to correlate the cardiomyocyte integrity of vaccinated and infected dogs with their levels of these cytokines because cardiomegaly, a characteristic of Chagas disease, is attributable to local inflammatory processes related to the activation of nuclear factor kappa B (NF-kappa B) induced by Toll-like receptor 2 (TLR2) and IL-1 local production [52].