mUC-MSC paracrine can alleviate renal fibrosis in the DN cell model via inhibition of MFT caused by TGF-β1, blocking mesangial cell proliferation induced by PI3K/Akt and MAPK signaling pathways, and elevating the levels of MMP2 and MMP9. This evidence concerns the gene TGFB1 and liver dysplastic nodule.