Herein, we investigated the role of mUC-MSC paracrine in regulating the expression of MMPs, and found that MSC-CM could elevate the levels of MMP2 and MMP9 in mesangial cells cultured in HG (Figure 4(c)), which is in accordance with a recent study showing that the upregulation of MMP9 is related to the attenuation of bone marrow-derived MSCs for DN in diabetic rats [19]. The gene discussed is MMP9; the disease is liver dysplastic nodule.