The mechanisms by which mUC-MSC paracrine attenuates renal fibrosis involve the inhibition of MFT triggered by the TGF-β1/Smad2/3 signaling pathway and mesangial cell proliferation mediated by the PI3K/Akt and MAPK signal transduction pathways, and elevating MMP levels. The gene discussed is AKT1; the disease is renal fibrosis.