Netrin-1 has been shown to protect against a myocardial ischemia-reperfusion injury and to reduce infarction size by inhibiting apoptosis and increasing myositis function through ERK1/2 inactivation immediately followed by NO production from serine 1177-phosphorylated eNOS in cardiac myocytes [10]. This evidence concerns the gene NTN1 and myocardial ischemia.