Also, a study on breast cancer cells (MDA-MB-231 and MCF-7) showed that Zerumbone could lead to G2/M phase cell cycle arrest associated with Bax/Bak-mediated apoptosis and downregulation of cyclin B1, Ddk1, Cdc25C, and Cdc25B [30]. This evidence concerns the gene CCNB1 and breast carcinoma.