Conversely, the hippocampal protein and mRNA levels of IL-4, IL-10, and TGF-β were lower in the AT/Nrf2-KO mice than in the AT/Nrf2-KO mice (Figures 5(a) and 5(b), lower panel), which suggested that Nrf2 deficiency might aggravate the activation of microglia and astrocytes prior to the augmented proinflammatory response in AT mice. Here, IL10 is linked to ataxia telangiectasia.