TGFB1 and ataxia telangiectasia: Conversely, the hippocampal protein and mRNA levels of IL-4, IL-10, and TGF-β were lower in the AT/Nrf2-KO mice than in the AT/Nrf2-KO mice (Figures 5(a) and 5(b), lower panel), which suggested that Nrf2 deficiency might aggravate the activation of microglia and astrocytes prior to the augmented proinflammatory response in AT mice.