In addition, mediators such as endothelin-1 (ET-1), angiotensin II (ANG-II), and cyclooxygenase-derived (COX) eicosanoids also compromise endothelium-dependent vasodilation, resulting in increased vasoconstrictor tone, which eventually drives to CVDs, such as hypertension [33, 34]. This evidence concerns the gene EDN1 and hypertensive disorder.