TNFRSF4 and interstitial lung disease: Similarly, very few biomarkers have been proposed up till now for ILD detection in patients with SS, mainly proteins associated with damage and turnover of alveolar epithelial cells as lung epithelium-derived surfactant protein (SP-D), glycoprotein Krebs von den Lungen-6 (KL-6), CCL18, and soluble OX40 [54].