TNF and acute respiratory distress syndrome: By dynamically observing the effect of QBD on the expression of serum cytokines TNF-α, IL-8 and IL-10 in rats with ALI induced by non-invasive instillation of endotoxin (LPS, 2 mg/kg) solution through larynx, He et al. [34] found that QBD could regulate the imbalance of pro-inflammatory and anti-inflammatory factors during ALI, alleviate pulmonary inflammatory injury, and thus protect lung tissue.