ESR1 and neurodegenerative disease: Targets with the most degrees among the 49 targets were as follows: thrombin, prostaglandin G/H synthase 2, eNOS, estrogen receptor, and β-adrenergic receptor; the top diseases that were most relevant to MHC were as follows: atherosclerosis, cardiovascular disease, hypertension, thrombosis, and neurodegenerative diseases, implying that MHC may be also effective in the treatment of these diseases.