Due to the significant effect of WWQZS for lowering cholesterol in pharmacology experiments above, the protein expression of HMGCR, CYP7A1, p-AMPKα, and p-ACC for cholesterol metabolism was evaluated in livers of WWQZS-treated hyperlipidemia hamsters by Western blotting. The gene discussed is HMGCR; the disease is hyperlipidemia.