Given that the regulation of lymphocytes on the activation of HSCs depends on the function of lymphocyte subsets and that CD4+T cells have been implicated in the pathogenesis of hepatic fibrosis [18], we observed that the number of CD4+T cells was lower in the patients of the NAs group and NAs + FZHY group than that from the control subjects. Here, CD4 is linked to Hepatic fibrosis.