AKT1 and malignant colon neoplasm: GOLPH3 has been validated as an oncoprotein and its expression in colon cancer tissues was significantly increased compared to normal tissues [5]; GOLPH3 overexpression can upregulate activation of the PI3K/AKT/mTOR and Wnt/β-catenin signaling pathways, promote proliferation, and induce apoptosis in colon cancer cells.